Progress of ProTherm: Thermodynamic Database for Proteins and Mutants
نویسندگان
چکیده
Thermodynamic data for proteins are important for understanding the mechanism of protein stability. Pfeil [1] collected a set of thermodynamic data on protein folding and stability from experimental studies. Recently, we have developed an electronically accessible Thermodynamic Database for Proteins and Mutants (ProTherm) [2], which includes several thermodynamic data (unfolding Gibbs free energy change, enthalpy change, heat capacity change, transition temperature, activity, etc.), structural information (secondary structure, solvent accessibility, etc.), measuring methods, experimental conditions and literature information. We have developed a WWW interface to facilitate searching the database and sorting outputs. At present, the number of data has been increased to more than 5,500 covering the latest experimental data and several new features have been included in the database.
منابع مشابه
Recent Developments in ProTherm: Thermodynamic Database for Proteins and Mutants
Due to the rapid progress in genome analysis, complete genome sequences of many organisms become available. Now proteins are the next target for intensive study, as evidenced by the emerging fields such as structural genomics and proteome analysis. In order to elucidate molecular function of proteins, we need to have knowledge of their amino acid sequence and structure. The sequence and structu...
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